Pseudomonas aeruginosa thrives in hostile environments by tightly regulating zinc (Zn) homeostasis, with the CzcRS two-component system playing a pivotal role in Zn resistance and broader adaptive processes. This study used ChIP-seq to map CzcR binding sites under zinc sufficiency (ZS) and zinc excess (ZE) conditions, revealing its dual role in maintaining physiological robustness and orchestrating Zn detoxification and virulence modulation.
Key findings:
- 32 CzcR binding sites were identified under ZE, potentially regulating 39 genes, many linked to virulence, antibiotic resistance, and stress response.
- 10 binding sites were detected under ZS, revealing distinct targets and basal CzcR activity.
- Seven and four novel CzcR-regulated genes were identified under ZE and ZS, respectively, primarily involved in bacterial virulence.
For more information, see the published paper.
